Read Microrna in Development and in the Progression of Cancer

Microrna in Development and in the Progression of Cancer

Rameshwar Pranela Singh Shree RAM

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Description:miRNAs are a class of endogenous, small non-protein coding RNA molecules ( 22 nucleotides) which are novel post-transcriptional regulators of gene expression.?Since we have hundreds of miRNAs, the major challenge is now to understand their specific biological function. In fact the experimental evidence suggests that signaling pathways could be ideal candidates for miRNA-mediated regulation. Several studies suggest?that miRNAs affect the responsiveness of cells to signaling molecules such as WNT, Notch, TGF- and EGFR.?Altered expression of particular miRNAs has been implicated in the onset and development of cancer and could be used as potential biomarkers for the disease.Recently, many studies have found miRNAs have crucial regulatory roles in Cancer stem cells (CSCs) a kind of tumor initiating cells (TICs) and dormancy. Findings also suggest that DNA methylation may be important in regulating the expression of many miRNAs in several cancer initiating cells. Several miRNAs are known to either upregulated or downregulated in CSCs when compared to non-cancerous cells from the same tissues. CSCs are a small subpopulation of cells identified in a variety of tumors and involve in self-renewal, differentiation, chemoresistance and tumorigenesis. The volume will give a comprehensive account of?important advancements in the area of miRNAs and cancer.We have made it easy for you to find a PDF Ebooks without any digging. And by having access to our ebooks online or by storing it on your computer, you have convenient answers with Microrna in Development and in the Progression of Cancer. To get started finding Microrna in Development and in the Progression of Cancer, you are right to find our website which has a comprehensive collection of manuals listed.
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Pages: 410

Format: PDF, EPUB & Kindle Edition

Publisher: Not Avail

Release: 2014

ISBN: 1489980652

Description: miRNAs are a class of endogenous, small non-protein coding RNA molecules ( 22 nucleotides) which are novel post-transcriptional regulators of gene expression.?Since we have hundreds of miRNAs, the major challenge is now to understand their specific biological function. In fact the experimental evidence suggests that signaling pathways could be ideal candidates for miRNA-mediated regulation. Several studies suggest?that miRNAs affect the responsiveness of cells to signaling molecules such as WNT, Notch, TGF- and EGFR.?Altered expression of particular miRNAs has been implicated in the onset and development of cancer and could be used as potential biomarkers for the disease.Recently, many studies have found miRNAs have crucial regulatory roles in Cancer stem cells (CSCs) a kind of tumor initiating cells (TICs) and dormancy. Findings also suggest that DNA methylation may be important in regulating the expression of many miRNAs in several cancer initiating cells. Several miRNAs are known to either upregulated or downregulated in CSCs when compared to non-cancerous cells from the same tissues. CSCs are a small subpopulation of cells identified in a variety of tumors and involve in self-renewal, differentiation, chemoresistance and tumorigenesis. The volume will give a comprehensive account of?important advancements in the area of miRNAs and cancer.We have made it easy for you to find a PDF Ebooks without any digging. And by having access to our ebooks online or by storing it on your computer, you have convenient answers with Microrna in Development and in the Progression of Cancer. To get started finding Microrna in Development and in the Progression of Cancer, you are right to find our website which has a comprehensive collection of manuals listed.
Our library is the biggest of these that have literally hundreds of thousands of different products represented.

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Microrna in Development and in the Progression of Cancer

Microrna in Development and in the Progression of Cancer

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